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munib_ca 2 hours ago [-]
> This is intended to be read by AI- please just copy and paste the URL of this and have ChatGPT walk you through it. If you have AR glasses, even better, since the AI can walk you through the whole protocol.
What kind of magic is going on here, am I missing something?
alwa 8 minutes ago [-]
I suspect the intention is to give specific but dense notes with minimal explanation, on the theory that the LLM will fill in the appropriate hand-holding along the way
__MatrixMan__ 1 hours ago [-]
I've bee thinking about starting a company where I fish roots out of your sewer and identify the plant (by sequence if necessary) that you have to kill so your sewer doesn't collapse as soon as it otherwise would.
$100 to stave off that $10000 sewer replacement for a few years would be worth it to a lot of people
fragmede 34 minutes ago [-]
Do it!
SilentM68 3 minutes ago [-]
Reminds me of the Gloing Plant Project.
I never got my glowing flower but would have settled for the instruction manual, also never created :(
By the by, can't seen to bring up the actual site linked on this post.
Aurornis 3 hours ago [-]
I wish this had some discussion of the results. The earlier reports about this sensor and process were very mixed. It’s a cool process either way, but I’d like to know how usable the real world output can be.
dwa3592 3 hours ago [-]
This is so cool. Thanks for doing this. The fact that we have this in a palm sized object is just crazy. Also, if/when we have a similar sized device for doing CRISPR .... umm i should stop here - it's becoming the plot of Gattaca
If it's an US-based lab, aren't they subject to CLIA with all its retention requirements?
For $7.5k+ you get a guaranteed privacy (as other comments suggest, other properties may vary, but at least the data never leaves your home).
vibrio 3 hours ago [-]
I suspect there is a deep sequencing service that is non CLIA and cheap. True. they may not be trustworthy with the data. That said, there are steps here where the data is put into Claude. Do we trust that ?
tzumby 2 hours ago [-]
I would never trust that. Instead I would use Claude to teach me genomics and build the tools to process and interpret data locally
mylons 2 minutes ago [-]
haha. hubris thy name is tzumby.
look up what isaac asimov had to say about genomic analysis.
j45 23 minutes ago [-]
A service is not the same as the equipment
armanj 1 hours ago [-]
one main marketing leverage of 23andMe, AncestryDNA, etc are fulfilling the curiosity of people who want to know which part of the world their genes are from. I guess that dataset should be preparatory.
TurdF3rguson 1 hours ago [-]
I'm too afraid I would learn something awful about myself.
whatever1 3 hours ago [-]
What is the accuracy in this ? Aka if I run the experiment 10 times how many differences will i get? I don’t have a physical sense on what would be a good number.
myhf 3 hours ago [-]
You would get a lot of differences, but the errors would cancel each other out with enough depth of coverage.
This technology's baseline accuracy is around 95% per base, so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other.
> so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other
This assumes random errors, which IIRC isn't the case for Oxford Nanopore.
Jules-Bertholet 3 hours ago [-]
Oxford Nanopore unfortunately has a high error rate (3-5%) compared to other sequencing technologies. And the errors are non-random
metalman 3 hours ago [-]
I am very impressed with the, why wait? just do it now approach to the future.
which while not here, IS there.
dekhn 3 hours ago [-]
Nothing about this is the future. Sequencing at home will not solve any major problems. It's mainly a fun exercise to demonstrate that sequencing has been commodified.
fragmede 1 minutes ago [-]
Knowing exactly why I have high LDL because of a specific mutation on my DNA is very much the future, imo.
ElenaDaibunny 32 minutes ago [-]
just a hobby project for now,pretty wild that this can be done at home.
bleepblap 3 hours ago [-]
> This is intended to be read by AI
Fuck this
tclancy 2 hours ago [-]
Man, doctors thought they had it bad before. For just a six yards I can play Peter Thiel at home! $6k invested so I can set an AI in YOLO mode to tell me I have some hyper-specific version of kennel cough?
“But that occurs in dogs?”
“You’re right. Let me look into actual gene sequencing instead of just guessing. I think the N is the load bearing letter.”
asveikau 3 hours ago [-]
Yeah that's weird. The instructions are not even hard to read. I don't understand what an LLM would add to this.
SuperSixFour 3 hours ago [-]
Literally left the article to come here and say this.
What kind of magic is going on here, am I missing something?
$100 to stave off that $10000 sewer replacement for a few years would be worth it to a lot of people
https://en.wikipedia.org/wiki/Glowing_Plant_project
By the by, can't seen to bring up the actual site linked on this post.
If you want it quick and cheap(er) - 599.00
For $7.5k+ you get a guaranteed privacy (as other comments suggest, other properties may vary, but at least the data never leaves your home).
look up what isaac asimov had to say about genomic analysis.
This technology's baseline accuracy is around 95% per base, so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other.
https://en.wikipedia.org/wiki/Coverage_(genetics)
This assumes random errors, which IIRC isn't the case for Oxford Nanopore.
Fuck this
“But that occurs in dogs?”
“You’re right. Let me look into actual gene sequencing instead of just guessing. I think the N is the load bearing letter.”